onkologia, chłoniak c.d
Maggie, kot, lat 10, kastrowany,
CHOP- Based Chemotherapy Protocol for Cats
Includes Cytarabine due to renal involvement
Treatment Week Drug, Dosage, and Route
Week 1 Vincristine, 0.025 mg/kg, IV
Prednisone, 2 mg/kg, PO
Week 2 Cyclophosphamide, 10mg/kg PO
Prednisone, 2 mg/kg, PO
Week 3 Vincristine, 0.025mg/kg, IV
Prednisone, 2 mg/kg, PO
W 4 Doxorubicin, 1mg/kg IV
Prednisone, 1 mg/kg, PO†
W5 Cytarabine 100mg/m2 s/c 2 x on consecutive days
W 6 Vincristine, 0.025 mg/kg, IV
W 7 Cyclophosphamide, 10mg/kg PO
W 8 Vincristine, 0.025 mg/kg, IV
W 9 Doxorubicin, 1mg/kg IV
W10 Cytarabine 100mg/m2 s/c 2 x on consecutive days
W 11 Vincristine, 0.025 mg/kg, IV
W 13‡ Cyclophosphamide, 10mg/kg PO
W 15 Vincristine, 0.025 mg/kg, IV
W 17 Doxorubicin, 1mg/kg IV
W18 Cytarabine 100mg/m2 s/c 2 x on consecutive days
19 Vincristine, 0.025 mg/kg, IV
21‡ Cyclophosphamide, 10mg/kg, PO
23 Vincristine, 0.025 mg/kg, IV
W 4 Doxorubicin, 1mg/kg IV
*A complete blood count (CBC) should be performed before each
chemotherapy treatment. If the neutrophil count is below
3000 cells/Ul, the practitioner should wait 5 to 7 days, repeat the
CBC, and then administer the drug if the neutrophil count has
risen above the 3000 cell/UL cutoff.
†Prednisone (1 mg/kg, PO) is continued every other day from this
point on.
¶If the patient is in complete remission at week 25, therapy
is discontinued and the cat is rechecked monthly for
recurrence.
IV, Intravenous; SC, subcutaneous, PO, oral.